Hae-Jeung Lee is a Professor at Eulji University in the Republic of Korea. She graduated and received her PhD from Seoul National University. She worked as a research fellow at Harvard Medical School and Harvard Public Health School. She carried out projects using various national nutrition surveys and health promotion programs and policies upon request from various Korean governmental agencies including the Ministry of Health and Welfare (MOHW), Korea Centers for Disease Control and Prevention (KCDC) and the Ministry of Food and Drug Safety (MFDS). She has conducted numerous randomized clinical trials as well.
Hypertension has been an important public health concern with a global prevalence of 26% among adults. Several studies reported that sugar-sweetened beverage consumption (SSBC) has been associated with higher blood pressure (BP) levels. These previous studies on the association between SSBC consumption and hypertension were conducted in Western countries. Therefore, we examined the association between hypertension prevalence and SSBC intake among Korean adults aged 19 through 65. This study used data from 2007-2009 Korea National Health and Nutrition Examination Surveys. We excluded subjects who had a diagnosis of or were receiving treatment for hypertension. Hypertension was defined as having a systolic blood pressure higher than 140 mmHg or a diastolic blood pressure higher than 90 mmHg. SSBC intakes were calculated using food frequency questionnaires for the past year. Odds ratios (ORs) for hypertension were assessed by using logistic regression and multivariable models. 14.5% of all subjects were classified as having hypertension. A high SSBC (>2.3 servings/week) was associated with a higher prevalence of hypertension after adjusting for confounding factors such as total daily energy intake, sodium intake and others. In the subgroup analysis by gender and obesity, SSBC was significantly associated with a higher prevalence of hypertension in obese women but was marginally associated in obese men. Further longitudinal and randomized clinical studies are warranted to confirm this causal relationship.
Jehan A Khan is currently a Faculty in biological sciences in King Abdulaziz University in Kingdom of Saudi Arabia.
Hepatitis is one of the major public health problems worldwide and was known to be the second cause of death after cancer. We designed this study to examine the potential hepato-protective effects of lycopene (Lyco) and selenium (Se) against galactosamine (Gala) induced hepatitis in rats. Seventy five (75) male albino rats were grouped into five of fifteen rats each. GP 1: Control. Animals in Groups (II-V) were injected i.p with Gala (30 mg/kg b.w daily) for 5 days. GP III: Rats were orally pre-treated with lycopene (15 mg/kg b.w). GP IV: Rats were pretreated orally sodium selenite (0.1 mg/kg b.w) by gavages. GP V; rats treated with both Lyco and Se. Results obtained showed that, the level of serum IL-6, TNF- α, NO and MDA were markedly increased as a result of Gala compared with control group. Administration of combined Lyco and Se reversed these effects and significantly reduced the elevated levels of IL-6, TNF-α, NO and MDA compared with Gala untreated. Administration of combined treatment resulted in a significant improvement of antioxidant activities (SOD, catalase) in gala injected compared with untreated. Non significant change was recorded in the activities of UDP-glucuronoyltransferase and sulphotransferase in animals injected with Gala but the activity of glutathione S-transferase was significantly elevated (p<0.001). Oral administration of LYCO+SE for 30 days in animals injected with gala showed improvement in the activity of glutathione S-transferase as compared with non treated rats (P<0.001) but not returned to normal. In conclusion; the combined effect of Lyco+Se showed a potent hepato-protective action against Gala induced hepatitis. It was concluded that, Lyco+Se possess hepato-protective action against hepatitis induced by galactosamine through inhibition of release of inflammatory mediators and enhance antioxidant capacity.